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Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality

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DeHart DN, Fang D, Heslop K, Li L, Lemasters JJ, Maldonado EN

More specifically, AX supplementation enhances the abundance of anaerobic genera such as Alistipes and Alloprevotella , both known to produce short-chain fatty acids (acetate, propionate, butyrate) and amino acidderived metabolites (e.g., pyruvate, isoleucine) that act as signaling molecules for mitochondrial activation and UCP1 transcription in adipose tissue [73,74]