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This pathway of xCT induction by neuronal activity was also prevalent in the hippocampi of epileptic patients, pointing to its potential role in epilepsy, probably via the upregulation of extracellular glutamate 41

The alkaline environment of the cytoplasm leads to histone acetylation, gene expression and increased protein synthesis, whereas the acidic conditions in the TME contribute to maximal P-gp catalytic activity (Assaraf et al., 2019)

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Ali AA, Abd Al Haleem EN, Khaleel SAH, Sallam AS

respiratory capacity, oxidative phosphorylation, and fatty acid -oxidation), produces ATP and lipids, induces amino acid and heme biosynthesis, and generates/sequesters reactive oxygen species (ROS) [54]

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