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Discussion In the kidneys, inorganic Hg species accumulate mainly in the proximal tubule cells, causing renal injury by oxidative stress mechanisms 9

The process of protein oxidation begins when ROS interact with specific amino acids, such as cysteine, methionine, and tyrosine, which contain sulfur or aromatic groups that are highly susceptible to oxidation

Imbalanced histone modification can lead to tumor development, and methylation and acetylation loss of histone H3 and H4 residues have been shown to be markers of tumor cells (Ray-Gallet and Almouzni, 2022)

Tang W, Li Y, He S, Jiang T, Wang N, Du M, et al

Possible hepatotoxicity mechanisms are thought to be CYP450 inhibition, reduction in liver glutathione content, or inhibition of COX activity (4) (15)

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans