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10.1016/s0895-4356(01)00425-5 52 EldeebM

Most patients begin with a weekly loading phase for 48 weeks, followed by monthly maintenance, with no downtime

120,121,122 Totally, adherens junctions are fundamental for the integrity of BBB, any change of adherens junctions may disrupt inter-endothelial cell connections
one patient out of five develop end-stage hepatocellular carcinoma [236,237]
Pincus T: Folic and folinic acid supplementation reduces methotrexate gastrointestinal side effects in rheumatoid arthritis

Increasing anabolic potential but also hypertrophy risk in non-target tissues
