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Normally, repair crews (blood vessels, fibroblasts, macrophages etc) take time to arrive and fix the damage especially in low-traffic areas like tendons and ligaments that dont get much blood flow
At the pre-processing step of the MRS data using MRspa, individual average files that were corrupted were removed
It also decreased the expression of the PI3K/AKT/mTOR pathway and the NF-/TGF- pathway, inhibited CK18 and COX2 activity, increased the concentration of BAX and P53 proteins, and decreased Bcl-2, IL-6, IL-1, MMP2, and MMP9
Table 2 Metabolic alterations in neurodegenerative diseases
Int J Biol Macromolecules (2023) 233:123169
Holbrook KA, Byers PH, Counts DF, Hegreberg GA
