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3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019

In this context, combining targeted ammonia metabolism intervention (e.g., using the GLS1 inhibitor CB-839) with CAR-T cell infusion not only blocks tumor cell utilization of ammonia but also enhances T cell adaptability through metabolic plasticity, thereby simultaneously alleviating the immunosuppressive microenvironment and prolonging CAR-T cell persistence (156, 159)

As with any parenteral product, there is a risk of infection, phlebitis or thrombophlebitis if aseptic technique or venous access is inadequate

Subcellular localization of miRNAs and implications in cellular homeostasis

In: Gupta, D., Palma, J., Corpas, F

Cognitive performance of MDMA-treated rhesus monkeys: Sensitivity to Serotonergic Challenge
