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This is because it is water-soluble, so most ingested B12 is actually flushed out in the urine

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Work from Hei Sook Suls lab demonstrated that PNPLA2 in adipocytes was required to maintain a BAT phenotype through the regulation of PPAR, a nuclear transcription factor (140)

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In the basal state PNPLA2 has weak hydrolytic activity which is greatly increased by the co-lipase alpha/beta hydrolase domain-containing protein 5 (ABHD5, also known as CGI-58) by greater than 20-fold (30)

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