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Both the burden and location of acute and chronic ischemic lesions are associated with PSCI, but their independent contributions have rarely been studied in large cohorts

44 - 44, presented at 15th World Congress on Cancers of the Skin, SCOTLAND, Edinburgh, 03 September 2014 - 06 September 2014, Conference Papers | 2014 Kefford R

10.1093/eurheartj/ehu179 43

This is where things get tricky, because different pharmacies use different concentrations

When serum B12 results are equivocal or clinical suspicion remains high despite normal B12 levels, additional tests may be requested: Methylmalonic acid (MMA) : Elevated levels indicate functional B12 deficiency at the cellular level, though availability may be limited in primary care and levels can be elevated in renal impairment Homocysteine : Also elevated in B12 deficiency, though less specific and also affected by renal function Intrinsic factor antibodies : To investigate pernicious anaemia, the most common cause of B12 deficiency in the UK Anti-parietal cell antibodies : May be tested if pernicious anaemia is suspected but intrinsic factor antibodies are negative Identifying the underlying cause is crucial for appropriate management