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Description
The impairment of KP in ALS is confirmed by the following evidence: higher serum tryptophan, cerebrospinal fluid (CSF), KYN and QA and a decrease in serum picolinic acid levels in ALS patients

Carbamidomethylation of cysteine residues (+57.021 Da) was set as a static modification, while methionine oxidation (+15.995 Da) was chosen as a variable modification

doi 10.1038/s41598-024-54201-x
Copper- and zinc-containing superoxide-dismutase, manganese-containing superoxide dismutase, catalase and gtutathione peroxidase in normal and neoplastic human cell lines and normal tissue

12, TP H Ch Minh

This stress is linked to the accumulation of cytotoxic compounds, enzyme failures, lipid peroxide formation, and ultimately, the death of substantia nigra cells, contributing to PD progression (30)
