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Many compounds that looked effective in animals later failed human trials or revealed safety concerns
Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)
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The levels of IGF-1 prior to treatment, during treatment for different stages of puberty, and after treatment are illustrated in Figure 4 and Table 7
Molecular mechanisms of off-on switch of activities of human IDH1 by tumor-associated mutation R132H
V.YemenS.BorowitzM.LiuL.PlappM.SunF.et al (2010)
