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Goadsby PJ, Edvinsson L, Ekman R

Science 262 : 689695 (1993)

The anti-folateanti-cancer chemotherapeutic drug methotrexate (Table 1) is used clinically for curing multiple cancers, especially acute leukemia, despite its serious side effects

In other words, it's a medication that targets and binds to the receptors for the GLP-1 peptide, which is part of the bodily systems that regulate hunger and satiation, as well as blood sugar control

Cheng T, Sudderth J, Yang C, Mullen AR, Jin ES, Mats JM, DeBerardinis RJ

They may also suggest trying Botox if you dont tolerate migraine medications well
