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Compounds like dimethyl malonate (MAN) facilitate the recovery of energy metabolism by mitigating oxidative stress, optimizing glucose utilization, minimizing the accumulation of glycolytic byproducts, and reinstating the functionality of LDH, thereby enhancing cellular metabolic efficiency (210)

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These findings highlight the significant reduction in HMGB1 expression and proinflammatory cytokine levels and the alleviation of intestinal inflammation achieved through sodium butyrate administration

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Together they create a healing environment that neither achieves alone

Importantly, this is the first study to identify -EC in durian pulp extract as a potential neuroprotective biomarker