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Frequency and Duration of Administration: A single large dose might have a different effect profile than smaller, more frequent doses over an extended period

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7,8 Recent research has identified inflammatory mediators and signaling pathways as important factors in the onset and progression of disc degeneration

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Two main polarisations of TAMs include M1-like macrophages, which exhibit anti-tumour activities by stimulating the adaptive immune response and inflammation and, conversely, M2-like macrophages, which exhibit tumour promoting activities by suppressing the immune response in the TME [183]