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In conclusion, KD intervention appears to improve renal function in patients with DKD, and may slow disease progression

It has been found that cancer-associated fibroblasts (CAFs) have a greater dependence on Gln than tumor cells do and exhibit greater sensitivity to GLS inhibition ( 3 Regulation of Gln metabolism in tumors 3.1 ncRNAs regulate Gln metabolism ncRNAs play a crucial role in the occurrence and development of tumors

131 Because of its antioxidant properties, vitamin E had been proposed as a therapeutic agent, 139 , 140 , 141 but subsequent evaluation of large doses of the vitamin failed to demonstrate an ameliorative effect on anemia

Nrf2 is inhibited by Kelch-like ECH-associated protein 1 (Keap1): specifically, it increases Nrf2 proteasome-mediated degradation [20,21]

Although tremendous efforts have been made to achieve outstanding advances in this research field, further investigations still face the following challenges

FDA approves first deuterated drug: Nature Publishing Group
