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Notably, NEs function as multifunctional lipid-based nanosystems that combine enhanced permeability, tissue and cellular targeting, imaging, and therapeutic efficacy

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300 Using a mouse melanoma model, the researchers confirmed that the intrinsically active -catenin signal of the tumour led to T cell rejection and resistance to anti-PD-L1/anti-CTLA-4 monoclonal antibody treatment

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PubMed PMID: 25309649

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BPC-157 has been extensively studied in animal models of gastrointestinal pathology

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In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )

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