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27 It can be achieved via chronic energy restriction, the most extreme form of which is short-term starvation (STS, corresponding to water-only fasting) or intermittend fasting (IF) regimes such as only eating every other day

PLoS One 13 , e0203084 (2018)

Glutathione depletion is particularly linked to neurodegenerative disorders, pulmonary diseases, immune disorders, cardiovascular diseases, and chronic geriatric conditions [50]

Through metabolomics approaches, we found that mutationally activated KRAS strikingly increased intracellular cystine levels and glutathione biosynthesis

These findings, in conjunction with prior studies [193], corroborate the mPFCs centrality in the development of anxiety and depression, underscoring the necessity for a deeper exploration into the regulatory dynamics of lactylation modifications within this region

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