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15 Being a powerful antioxidant, glutathione plays a critical role in several metabolic pathways: DNA and protein synthesis, amino acid transport, enzyme activation, immune system function, scavenging free radicals eg hydrogen peroxide, cofactor in Phase I cytochrome P450 enzyme-mediated detoxification, amino acid translocation across cell membranes, detoxification of xenobiotics, maintenance of sulfhydryl groups of proteins, mitochondrial function and maintenance of mitochondrial DNA, catalysis of exchange reactions and many more

[DOI] [PubMed] [Google Scholar] 14.Murakami K, Kondo T, Ohtsuka Y, Fujiwara Y, Shimada M, Kawakami Y

Additionally, NitroSynapsin reduced the level of VGLUT2, the VGLUT1/VGAT ratio, and VGLUT2/VGAT ratio, as well as the number of hippocampal GFAP-positive cells [52]

This protein is calcium-dependent and binds to phospholipids

This agrees with the known effect of APR-246 as a disruptor of the redox system

doi: 10.1124/jpet.116.237503