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2.6 Software Datasets containing PK and covariate data from each trial were converted to a format compatible with the modelling software NONMEM (ICON Development Solutions, Ellicott City, MD, USA), Version 7.3

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While a powerful approach, challenges to optimizing proteins through glycoengineering remain, including difficulty in predicting a priori how changing glycopatterns will influence protein properties and loss of activity upon varying glycosylation identity and sites