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This may be related to the findings that high levels of ROS can mitigate metastasis and tumorigenesis, for example in cancer cells detaching from the extracellular matrix [42,43]

The effectiveness and risks of long-term opioid therapy for chronic pain: A systematic review for a National Institutes of Health Pathways to Prevention Workshop

Kelley RK, Verslype C, Cohn AL, Yang TS, Su WC, Burris H, et al

Green Chem 26 , 54415451 (2024)

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Cognitive issues like memory loss, difficulty concentrating, or mood swings may also indicate a deficiency