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5 , e38 (2007)

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Obi P.C., Njoku G.H., Mbaike A.C., Ihim A.C., Nwako O.F., Anyanwu A.C., Ohiri J.U., Nwazor E., Ubani B.C., Ogbonna S.U., et al

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Fe 3+ , Cu 2+ ) it is known to directly target cellular lipids, proteins, nucleic bases, causing DNA base modification or fragmentation[5]

Secondly, ROS has a dose dependent effect on activity of proteins leading to differential downstream outcomes [140], which are distinct in the setting of exogenous and endogenous ROS, and need to be evaluated in phase 1 dose finding studies with appropriate pharmacodynamic/ pharmacokinetic readouts

Mucosal Immunol 2014;7:684693