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In people who smoke or inhale particles or other oxidants, there is potential inflammation that involves invasion of neutrophils from the blood through the endothelial and epithelial cells into the air spaces

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Side effects are generally minimal but can include redness, swelling, or mild tenderness at the injection sites

Due to advances in the care of patients, different studies reveal increasing survival rates, with ensuing concern about the possible appearance of further associated diseases such as cardiovascular [14, 15]