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In addition, p -cresol is also likely to deplete GSH as, like APAP, it is a substrate for oxidative metabolism, forming reactive metabolites (RMs) via CYP P450-mediated metabolism (both a quinone methide via CYP2D6, 2C19, 1A2, 1A1, and 2E1 and a 4-methyl- o -hydroquinone that is further oxidized to 4-methyl-1,2-benzoquinone, mainly via CYP2E1 but also CYP1A1, 1A2, and 2D6)36 potentially reducing the ability of the host to simultaneously detoxify APAP-derived RMs

doi: 10.1210/jcem.75.3.1381372 60 BaxterRCBrysonJMTurtleJR

L-citrulline helps the body rid itself of ammonia, a by-product of intense exercise

Expression of the NADK2 gene is highest in the liver, being 5-6 fold higher there than in any other tissue

Bakeberg MC, Jefferson A, Riley M, Byrnes M, Ghosh S, Mastaglia FL, Horne MK, McGregor S, Stell R, Kenna J, Walters S, Hince D, Anderton RS (2019) Elevated serum homocysteine levels have differential gender-specific associations with motor and cognitive states in parkinsons disease

Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma