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5A) and NPBs ( p = 0.048

Nature , 532 (7598), 255258

Therefore, the result of the desirable properties obtained with the incorporation of cereblon ligands in the construction of PROTACs, together with the excellent therapeutic results published in recent years, obtained by forced induction of the degradation of a specific POI by cereblon-based PROTACs in vitro, ex vivo and in vivo, and for different types of diseases, make this type of PROTACs the leaders in the field of TPD

Z.AshfaqM.JavedM

Jansonius JN

Additionally, an increased presence of intraepithelial lymphocytes further reinforces their immunogenic nature, indicating a potential for responsiveness to immunotherapy (46)