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Rat-to-human translation is unreliable

We identified distinct inter-domain LBD motion in the intact LBD state of GluK2/K5em-5-IW-Kyn compared to GluK2/K5em-CNQX

The tonicity is preferably from half to twice as high as that of physiological saline, more preferably from three-quarters to one and a half as high as that of physiological saline

Mitragynine and 7-hydroxymitragynine both bind to the human -opioid and -opioid receptors (hMOR, hKOR) with nanomolar affinity, and function as partial agonists at the -opioid receptor and weak antagonists at -opioid and -opioid receptors 14,15