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Even so, moving from this biochemical function to clinical outcomes is not always straightforward: the evidence can be heterogeneous and depends on dose, duration, the population studied and lifestyle variables

S1PR2 is expressed on various cell types relevant to the TIME, including myeloid cells (macrophages, monocytes, neutrophils) and certain cancer cells, positioning it to potentially influence tumor-associated inflammation and progression (103)

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Thus, the increase of ATF4-mediated integrated stress response (ISR) in T315I-Bcr-Abl 32D cells remodels dTTP and GSH biosynthesis, thus avoiding DNA replication stress

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