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112 While H 2 S-mediated protein per-sulphidation is relevant in any cellular compartment, mitochondrial H2S generation is particularly relevant for cellular bioenergetics, as detailed later in the article

Under oxygen enrichment, the primary function of glycolysis is to produce intermediate metabolites that provide source materials for biosynthetic pathways, whereas under hypoxia, the primary role of glycolysis is to provide ATP for cell survival (37)

Skeletal muscle functions not only as a mechanical organ but also as an endocrine organ, releasing myokines and metabolites that influence brain metabolism and plasticity, while the brain regulates muscle activity via neural and hormonal pathways

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Rational dose selection and proper use of opioid drugs, through knowledge of their mechanisms of action, allow avoiding side effects related to their use