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( C ) Overexpression of Chac1 in liver assessed by immunoblot

Under conditions of oxidative stress, NRF2 associates with Keap1 and activates the expression of downstream target genes containing AREs, such as ferric heavy chain proteins (FTH1) and ferric light chain proteins (FTL), which encourages GSH synthesis and regenerates NADPH to compete with ROS production (83)

Supporting Detoxification and Immunity GSH aids detoxification by binding to toxins in the liver for elimination and supports immunity by promoting healthy immune cell function

doi: 10.1371/journal.pone.0304253 73 PorcariS.BenechN.Valles-ColomerM.SegataN.GasbarriniA.CammarotaG.et al
