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In the case of cellular stress, sustained IMM depolarization leads to the stabilization of PINK1 on the OMM

doi: 10.22270/jddt.v2i3.163

Although they are not able to catalyze glutathione S -conjugation reactions at significant rates, they are considered to belong to the glutathione S -transferase (GST) superfamily (Dixon and Edwards, Glutathione peroxidase (GPX) Although GSSG could be generated as a product of GSH-dependent DHA reduction, genomics has revealed the complexity of the plant antioxidative system and identified several GSH-dependent enzymes that may play more direct roles in peroxide metabolism

Many widely used chemotherapy drugs, including platinum-based agents (oxaliplatin, cisplatin, carboplatin), taxanes (paclitaxel, docetaxel), vinca alkaloids (vincristine, vinblastine), proteasome inhibitors, and thalidomide analogues may cause direct neurotoxicity and CIPN (Zajczkowska et al., 2019)

Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models

[124] [135] Moreover, clomipramine may be able to achieve more complete occupancy of the SERT at high doses, at least relative to fluvoxamine