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83 Soy proteins, such as soybean trypsin inhibitor (STI) and Bowman-Birk inhibitor (BBI), inhibit the activation of these cell receptors, and as a result, phagocytosis of melanosomes into keratinocytes is reduced leading to reversible depigmentation

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These changes, along with its protein expression, significantly correlate with an increase in microvessel density, indicating that aberrant ubiquitination of HIF-1 may be linked to invasion and metastasis of VHL-deficient tumors[60]

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