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While levodopa is still considered the gold-standard of symptomatic efficacy, its chronic use is associated with the development of response oscillations and drug-induced dyskinesias in a majority of patients

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Mechanistically, proteomic and pathway enrichment analyses revealed broader and deeper inhibition of Pin1-regulated oncogenic and metabolic networksincluding Wnt/-catenin, NF-B, and CDK signalingcompared to either drug alone

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