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These findings led to the ongoing PROOF-HD phase 3 trial (NCT04556656), which aims to further evaluate its impact using functional endpoints

Fujiwara T, Hato N, Nakagawa T, Tabata Y, Yoshida T, Komobuchi H, Takeda S, Hyodo J, Hakuba N, Gyo K

Indika N-LR, Frye RE, Rossignol DA, Owens SC, Senarathne UD, Grabrucker AM, Perera R, Engelen MP, Deutz NEP (2023) The rationale for vitamin, mineral, and cofactor treatment in the precision medical care of autism spectrum disorder

It compares with rice from India, which had about a quarter of that amount.[ref] In fact, people eating a gluten-free diet in the US are, on average, exposed to a lot more arsenic from rice

The hypothesis of the gain of function in GCase theorizes that the mutant form of protein is recognized as misfolded, thus placing stress on mechanisms of protein degradation and interfering with -synuclein breakdown and consequent endoplasmic reticulum stress, as observed in autophagy perturbations in cells derived from patients with GBA1 -associated PD (Fernandes et al., 2016)

Because B12 is obtained through consuming animal-based products such as meat, milk, cheese, and eggs, vegans are at a higher risk of developing a b12 deficiency