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doi: 10.1111/j.1523-1755.2005.00214.x

Peak antioxidant effects show up around 36 months of daily use

doi:10.1016/0014-5793(80)80564-3

Some insight into this aspect of safety is provided by studies evaluating the effects of vitania sluggard extract on pregnant rats

Common Topical Application Patterns Use case Facial anti-aging (community use) Concentration 1-2% Frequency Once or twice daily Cycle length 8-12 weeks Use case Scalp / hair-research interest Concentration 1-3% Frequency Daily Cycle length 12+ weeks ongoing Use case Compounded post-procedure Concentration 1-2% Frequency Per clinician guidance Cycle length Per clinician guidance Topical concentrations are typically expressed as percent weight
