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In Regard to Byun et al

10.1016/j.scitotenv.2018.06.084 [DOI] [PubMed] [Google Scholar] Wu X., Chen L., Zeb F., Huang Y., An J., Ren J

These clinical manifestations are probably secondary to mitochondrial dysfunction in the heart and smooth muscle (particularly the gastrointestinal tract) and an autonomic nervous system insult (neurotransmitters)

We also thank the Hospital de Clnicas de Porto Alegre, Rede IEM Brazil (Inborn Errors of Metabolism Network Brazil) and the funding agencies that made this work possible, CAPES and FIPE