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Hepatocytes in Mat1a-/- mice showed a higher expression of cytochrome P450 family 2 subfamily E member 1 (CYP2E1) and a reduction in mitochondrial membrane potential (6264)

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Effects of SAG on Oxidative Stress Induced by CCl4 Chronic Exposure CCl4 intoxication downregulated SOD (Figure 3A) and GSH (Figure 3B) compared to the sham groups

Thus, the NLRP3 inflammasome serves as a key mechanistic link between the initial toxic insult and the ensuing inflammatory response in APAP hepatotoxicity

Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway