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Nasal powders of quercetin--cyclodextrin derivatives complexes with mannitol/lecithin microparticles for nose-to-brain delivery: in vitro and ex vivo evaluation

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Although targeted agents have achieved success in the treatment of RA, various targeted carriers are characterized by multiple limitations, such as minor drug loading, poor stability, immature preparation techniques, lack of pharmacokinetic models, immature quality of evaluation indexes, insufficient effectiveness, and a poor safety profile

The development and improvement of ribonucleic acid therapy strategies

Most of the compounds synthesized showed satisfactory inhibitory activity, with those with the phenylsulfonamide group as a substituent standing out as having good XO inhibitory activity

Once opened, handling and disposal should follow internal laboratory protocols