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More investigations are needed to fully understand the effects of this enzyme, especially with respect to the neuroplasticity of the ageing human brain

At present, the best therapeutic strategy is to maintain good glycaemic control and early screening and to provide prompt treatment when micro- and macrovascular complications are detected.73 The continuous improvement in knowledge about the molecular and progression mechanisms of diabetic angiopathy is essential for the development of newer and better pharmacological therapies, targeted not only to just maintaining normoglycaemia but also to control the essential factors that contribute to the inflammatory state of diabetes

doi: 10.1016/s0006-2952(02)01172-3

Furthermore, several point mutants within SNCA have been identified in early onset PD and related synucleinopathies (A30G [10]/P [11], E46K [12], H50Q [13, 14], G51D [15, 16], A53T [17]/E [18, 19]/V [20], E83Q [21])