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For example, pro-inflammatory factors (e.g., tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6), etc.) (9295), inflammatory mediators (e.g., prostaglandins (PGE2), nuclear kappa factor B (NF-B), and cyclooxygenase-2 (COX-2), etc.) (96, 97), and oxidative stress-associated molecules (e.g., ROS, RNS, and MDA, etc.) are upregulated after stroke (98, 99)

Cellular redox couples, mainly nicotinamide adenine dinucleotide (NAD + )/reduced NAD + (NADH), phosphorylated NAD + (NADP + )/reduced NADP + (NADPH), and reduced glutathione (GSH)/GSH disulfide (GSSG), are responsible for the bulk of cellular electron transfer (88, 106)

Low energy and oxidative damage cause aneuploidy and embryo arrest

Melville DB, Genghof DS, Inamine E, et al

146 Snchez-CastaedaC.CherubiniA.ElifaniF.PranP.OrobelloS.CapelliG.et al (2013)

[DOI] [PubMed] [Google Scholar] 139.Mannervik B, Board PG, Hayes JD, Listowsky I, Pearson WR