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Performing positive pixel density scoring on immunohistochemically stained post-mortem Brodmann Area 17 sections revealed that the progression of AD pathology was accompanied by decreased expression of nuclear receptor co-activator 4 and glutathione peroxidase 4 in the grey matter

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Because NNMT activity has been associated with metabolic efficiency and cellular energy balance, researchers continue to explore how modulation of this enzyme may influence broader metabolic and biochemical pathways

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