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10.3389/fonc.2019.00541 100 MoraisM

Circ Res 2002

Circulation 112: 34513461, 2005 [DOI] [PMC free article] [PubMed] [Google Scholar] 61.Maron BA, Zhang YY, Handy DE, Beuve A, Tang SS, Loscalzo J, Leopold JA

The inability of the cell to repair the damage incurred may lead to the death of the cell

Apart from its role in DNA methylation, folate exhibits antioxidant properties that have been found to regulate the proliferation of cancer cells through three main mechanisms: (i) enhances the coupling of eNOS to cofactor tetrahydrobiopterin (BH4), hence inhibiting the formation of superoxide anion and the resulting peroxynitrite, a potent oxidant involved in various pathological conditions

These findings suggest a possible implication of hyperosmolar stress in the pathogenesis of fibrosis