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Free Radic Biol Med 37:755767 Hirst J, King MS, Pryde KR (2008) The production of reactive oxygen species by complex I

Once acetaldehyde is obtained from ethanol metabolism, aldehyde dehydrogenase (ALDH) converts it into acetate, but if the system is overloaded, the excess of acetaldehyde reacts with mitochondrial GSH (mGSH), depleting the mitochondrial pool [143]

American Journal of Respiratory and Critical Care Medicine, 156 (2)

Circulating glutathione is primarily cleared by the kidney

A recent review highlighted the significance of the Nrf2-ARE signaling pathway in CVD [75,76]
