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Metabolic environment in substantia nigra reticulata is critical for the expression and control of hypoglycemia-induced seizures

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1A and B, adapted from [55])

DAO may be reduced for a number of reasons, including medications that act like intestinal DAO blockers, genetic polymorphisms (SNPs) that affect DAO activity, gut dysbiosis , and reduced nutrient cofactors that are required for DAO and other histamine pathway enzymes to work efficiently

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( C ) Representative histogram showing flow cytometry analysis of sorted CD105 + EPCR + endothelial cells (left) and heatmap showing differentially regulated genes in endothelial cells (right) from PAR2-G37I, PAR2-R38E, and WT mice ( n = 3/4/4)