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Table 1: Vitamin B12 treatment methods compared in this study The effectiveness of both vitamin B12 supplementation methods In both groups, vitamin B12 deficiencies were treated for all patients over the course of 6 months, showing no significant difference in concentration between oral or intramuscular supplementation

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Feeling depressed Feeling irritable Seeing big changes in the behaviors and feelings you often have The longer you go without the B12, the more severe these symptoms will become

Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

[2] [16] Dietary deficiency without neurological features: Initial loading doses followed by maintenance therapy, with consideration of oral supplementation in appropriate cases