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A.TimbolG.LiuJ.BasarahE.KepeV.et al (2010)

This engagement subsequently enhances the mRNA expression of pro-inflammatory cytokines

2 (2006): 128139, 10.1089/NEU.2006.23.128

Despite their potential, polyphenols remain underutilized in functional foods and dietary supplements due to several physicochemical properties, including low epithelial permeability, poor solubility in gastrointestinal fluids, structural modifications during digestion, and limited oral bio-accessibility (128, 129)

PGC-1, a versatile coactivator

They are getting a different, less effective one
