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52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines

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The AMP genes -defensin 2/defensin-4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) are encoded by 1,25(OH) 2 D/VDR signalling in the immune cells, thus contributing to the innate immune defence (172, 173)

Simic, T., Mimic-Oka, J., Ille, K., Dragicevic, D

B) Schutz der fr die therapeutischen Effekte so wichtigen SH-Gruppe des Glutathions auf dem Weg durch biologische Kompartimente bis hin zum gewnschten Wirkort