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Undeniably, sometimes, either extreme acidic or alkaline pH conditions stimulate protein conformational changes, which promote protein aggregation, and most reported paraprotein interference cases have been reported in assays with extreme acidic conditions, like inorganic phosphorous, iron, and direct bilirubin, or extreme alkaline conditions, such as creatinine, total protein, and lithium

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These results agreed with those of Wilkens et al

Funding The current research was funded by Vice Chancellor for Research at Ahvaz Jundishapur University of Medical Sciences and Pars Behrouzan Jam Company

For example, amateur athletes may experience greater cognitive benefits from creatine supplementation than highly trained individuals, likely because amateurs have lower baseline levels of this substance in their bodies [31]

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