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[DOI] [PubMed] [Google Scholar] Heeba GH, Mahmoud ME, El Hanafy AA

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Xu Y-J, Au NPB, Ma CHE (2022) Functional and phenotypic diversity of microglia: implication for microglia-based therapies for Alzheimers disease

They found that high iMES is linked to VEGF pathway silencing, endothelial cell attenuation, immune modulation, EZH2 induction, BAP1/SETD2 depletion, and resistance to immune checkpoint inhibition (ICI)

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this suggests that exposure to heavy metals, cigarette smoke, and agrochemicals can have detrimental effects on oocyte multiplication, growth, and maturation
