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Indeed, clinical manifestations of vitamin B12 deficiency can become evident upon depletion of the body stores to as little as 5%-10%, which may occur several years (up to 10 years) after the initial exposure to metformin or to other risk factors or conditions predisposing to vitamin B12 deficiency[50]

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doi: 10.1002/ajim.22835

In addition, research suggests that the nutrient plays a role in mood and may have a place in helping to treat nerve pain

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