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Effect of administration route on the pharmacokinetics of cobalamin in elderly patients: a randomized controlled trial

When folate is insufficient or in the wrong form (synthetic folic acid), methylation stalls, SAM drops, and COMT function suffersleading to either too-fast clearance (when the system is overwhelmed) or too-slow clearance (when methylation is depleted)

2022;8(3): e09094

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Liu C., Zhang Q., Zhou H., Jin L., Liu C., Yang M., Zhao X., Ding W., Xie W., Kong H
