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We adjust the dose based on these parameters, and include ancillaries such as aromatase inhibitors where necessary and as agreed with the patient

Particularly, we found that mean plasma levels of Valine (U:140.9 mol/L, K:127.8 mol/L), Lysine (U:109.9 mol/L, K:95.7 mol/L), Threonine (U:67.5 mol/L, K:57.9 mol/L) and Tryptophan (U:2.9 mol/L, K:2.3 mol/L), fell below the expected ranges for healthy adolescents (UCSF Clinical Core Accepted Reference Ranges) for both those affected with konzo and their unaffected siblings

6 The CD4 neutralization protects from Con A-induced liver injury in BALB/c mice

Therapeutic induction of antigen-specific immune tolerance

10.1186/s12935-015-0168-2 48 ChistiakovD

Mader JS, Salsman J, Conrad DM, Hoskin DW