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The sam1/sam1 mutant cells likely exhibited decreased growth in this condition due to downregulated CDC21 expression (fold change of 0.62, p-value=0.0247), which encodes thymidylate synthase, and/or because RNR complex inhibition could create dNTP pool imbalances which in concert with less Cdc21 could cause more difficulty to interconvert between some deoxyribonucleotides in these mutant cells, thereby creating sensitivity to this condition (Fig 13)

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In the absence of impaired kidney function, an elevated MMA level in conjunction with elevated homocysteine suggests either a vitamin B 12 deficiency or a combined vitamin B 12 and folate deficiency (32)

The sections were counterstained with 3% uranyl acetate and 2.7% lead citrate

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

Hyperlipidemia and atherosclerosis are closely interconnected